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For leelee5675...
I thought I would repost an article written by a friend of mine on methamphetamines and dopamine. It might help you understand the changes in active addiction, and why it takes so long for the brain/chemicals to be repaired/restored. I am a recovering meth addict, and I was also married to a meth addict. I also have a 31 year old daughter who did considerable time incarcerated on felony drug charges related to meth.
Hopefully I can get one of the mods to pin this because I think it's a great resource for anyone to understand the damage that meth does to the brain/dopamine. It also lists some ways to help in early recovery with supplements and other various things.
Dopamine, Methamphetamines, and You
First things first -- What does dopamine do anyway?
1) Dopamine is critical to the way the brain controls our movements. Not enough dopamine -- can't move, or control our movements well. Too much dopamine? Uncontrollable/subconscious movements (like picking, tapping, repetitive moments, jerking, twitching). Remember that the heart is a muscle, too, and too much dopamine will result in increased pulse and blood pressure.
2) Dopamine controls the flow of information from other areas of the brain, especially memory, attention and problem-solving tasks. This becomes important when we talk about amphetamine-induced psychosis that is common in meth abusers.
3) When dopamine is released it provides feelings of enjoyment and reinforcement to motivate us to do, or continue doing, certain activities. Dopamine is released by naturally rewarding experiences such as food and sex. This pre-programmed reward system makes sure that people do eat, do desire to procreate, and basically survive. Without enough dopamine, people feel the opposite of enjoyment and motivation -- they feel fatigued and depressed, and experience a lack of drive and motivation.
How do brain chemicals like Dopamine work?
Brain chemicals, including Dopamine, are stored in cells, which you can think of like barrels full of that chemical. When something occurs like a good meal or great sex the brain pours out some dopamine from the dopamine barrels into an open space in the brain called a synapse. It floats around there. Think of the synapse like a street, and dopamine is like little cars driving around aimlessly on the street.
Across the street (not far) from the barrels of dopamine are Dopamine receptors. These receptors have little parking spaces on them that only fit Dopamine (or a substance VERY similar in chemical shape to Dopamine) into them, like a lock and key. As the Dopamine floats around in the synapse, it finds parking spaces at Dopamine receptors, and "plugs in" to the receptors. THIS is the point where we feel good, when the Dopamine is parked in a receptor's parking space. There are, however, a limited number of receptors with "Dopamine only parking" available, and each receptor has a limited number of parking spaces. So some of the dopamine may not be able to find a place to park.
When all the parking spaces are taken, the remaining dopamine that didn't find a place to park is normally recycled. There are "reuptake molecules" that do this -- think of them like tow trucks. They find the extra dopamine, and tow it back to the barrels of Dopamine so that it can be re-used the next time. After some time has passed, the receptors release the Dopamine that was parked in their parking spaces, and the tow trucks take those Dopamine molecules back to the barrel too.
The brain has a safety-check system that will destroy any excess Dopamine that isn't in a parking space, and didn't get picked up by the tow truck. There are special chemicals in our brains that will break down this extra dopamine. Think of this like the toxic waste crew coming in and sweeping up the street.
As a last resort, after repeated long-term over-stimulation, the brain will shut down Dopamine receptors so that nothing can park there ever again. Think of this like the demolition team coming in and permanently barricading off the driveways.
This is your brain on Meth!
So now that we have a basic understanding of how things work normally, I'll try to explain how things work when meth is ingested.
When someone eats, snorts, injects, or otherwise gets meth into their system, meth stimulates those barrels of Dopamine to pour out Dopamine. Meth continues to tell the cells to pour out dopamine until the body can break down the meth, which is typically 12 hours or so.
So Dopamine is poured out into the synapse (street) and finds parking spaces at dopamine receptors and makes the user feel high.
But meth is a tricky little chemical. It is shaped closely enough to Dopamine that the tow trucks get confused, and pick up meth thinking that it is dopamine. So the tow trucks are busy driving around hijacked by meth molecules leaving the extra Dopamine molecules floating around in the street (synapse). Well... that means the toxic waste crew comes in and destroys that dopamine that did not get recycled. So for the 12 hours or so it takes for the body to break down the meth, it is also spending that time destroying dopamine.
As long as the user keeps ingesting more meth, this process continues until there is not enough dopamine left to feel high from. When the user finally stops using, and the brain breaks down the meth molecules, the recycle trucks try to salvage what dopamine there is left, while the user crashes.
The end result of a "run" or "binge" on meth is a marked decrease in the amount of dopamine left in the brain. This leaves the user feeling exhausted, hungry, depressed, possibly suicidal and definitely unmotivated. They are literally suffering from a brain chemical imbalance. Self-inflicted mental illness.
How can the brain ever be normal again?
Well, luckily, the human body is pretty resilient. We do have the ability to make replacement dopamine. However, the body was not designed to need to do this in large quantities or in quick supplies. So we don't have a mass-production plant making dopamine. It's a 3 to 4 step process, too.
The process: Phenylalanine --> Tyrosine -->L-dopa --> Dopamine
Phenylalanine is the first "pre-cursor". It can be found in the following foods: soybean protein, frozen tofu, dried and salted cod, shellfish, lean meat, organ meat, skin-free chicken, cheese, milk, eggs, many seeds (watermelon, fenugreek, roasted soybean nuts), and chocolate. Equal artificial sweetener also contains Phenylalanine. The body can turn Phenylalanine into Tyrosine.
Tyrosine can also be found in food. This would eliminate the need for the body to synthesize it from Phenylalanine. One step closer to dopamine! Meat, dairy, eggs as well as almonds, avocados and bananas are good sources of Tyrosine.
From there, the body will convert Tyrosine into L-Dopa, and then on to Dopamine (and other neurotransmitters like norepinephrine).
So... to replace dopamine destroyed while high on meth, the recovering user must eat sources of Phenylalanine or Tyrosine.
To aid the body in making Dopamine, the person can use what dopamine they DO have left as often as possible. This tells the body that they need more of it. While you sleep, you use very little dopamine. Exercising, even just a walk around the block will use dopamine (remember, it controls movement). So setting a reasonable sleep schedule, and trying to get some exercise will help speed up recovery from Self-inflicted Dopamine Destruction (aka meth addiction)!
Be patient -- remember, we weren't designed to waste dopamine, we were supposed to be recycling it. The process of replenishing dopamine takes months. Studies show that recovering meth addicts who have abstained from meth use have about 80% of normal dopamine levels after 18 months of abstinence. This WILL be a long battle. It CAN be won.
What about the receptors that were destroyed?
Well, good news again. Even though those receptors can never heal or recover, the brain is able to use existing receptors and find new pathways to accomplish the same results. Some receptors will even get a home equity loan and build on extra parking spaces!
Are there any medicines that can help?
A doctor should always be consulted and included on any medication treatment for a recovering user. Many recovering addicts have found Wellbutrin (Bupropion) to be helpful after a few months of clean time. What Wellbutrin does is block some (not all) of the tow trucks for a little while so that the dopamine the person has left can be more effective. It does not, however, stimulate the barrels to pour out dopamine. The person has to have enough dopamine in their brain before Wellbutrin can help.
Health stores do carry supplements of Phenylalanine and Tyrosine. A recovering addict who finds it difficult to eat enough protein may benefit from a supplement. Again -- consult your doctor first.
Lori Pate
B.A Psychology
University of Texas at Austin
Hopefully I can get one of the mods to pin this because I think it's a great resource for anyone to understand the damage that meth does to the brain/dopamine. It also lists some ways to help in early recovery with supplements and other various things.
Dopamine, Methamphetamines, and You
First things first -- What does dopamine do anyway?
1) Dopamine is critical to the way the brain controls our movements. Not enough dopamine -- can't move, or control our movements well. Too much dopamine? Uncontrollable/subconscious movements (like picking, tapping, repetitive moments, jerking, twitching). Remember that the heart is a muscle, too, and too much dopamine will result in increased pulse and blood pressure.
2) Dopamine controls the flow of information from other areas of the brain, especially memory, attention and problem-solving tasks. This becomes important when we talk about amphetamine-induced psychosis that is common in meth abusers.
3) When dopamine is released it provides feelings of enjoyment and reinforcement to motivate us to do, or continue doing, certain activities. Dopamine is released by naturally rewarding experiences such as food and sex. This pre-programmed reward system makes sure that people do eat, do desire to procreate, and basically survive. Without enough dopamine, people feel the opposite of enjoyment and motivation -- they feel fatigued and depressed, and experience a lack of drive and motivation.
How do brain chemicals like Dopamine work?
Brain chemicals, including Dopamine, are stored in cells, which you can think of like barrels full of that chemical. When something occurs like a good meal or great sex the brain pours out some dopamine from the dopamine barrels into an open space in the brain called a synapse. It floats around there. Think of the synapse like a street, and dopamine is like little cars driving around aimlessly on the street.
Across the street (not far) from the barrels of dopamine are Dopamine receptors. These receptors have little parking spaces on them that only fit Dopamine (or a substance VERY similar in chemical shape to Dopamine) into them, like a lock and key. As the Dopamine floats around in the synapse, it finds parking spaces at Dopamine receptors, and "plugs in" to the receptors. THIS is the point where we feel good, when the Dopamine is parked in a receptor's parking space. There are, however, a limited number of receptors with "Dopamine only parking" available, and each receptor has a limited number of parking spaces. So some of the dopamine may not be able to find a place to park.
When all the parking spaces are taken, the remaining dopamine that didn't find a place to park is normally recycled. There are "reuptake molecules" that do this -- think of them like tow trucks. They find the extra dopamine, and tow it back to the barrels of Dopamine so that it can be re-used the next time. After some time has passed, the receptors release the Dopamine that was parked in their parking spaces, and the tow trucks take those Dopamine molecules back to the barrel too.
The brain has a safety-check system that will destroy any excess Dopamine that isn't in a parking space, and didn't get picked up by the tow truck. There are special chemicals in our brains that will break down this extra dopamine. Think of this like the toxic waste crew coming in and sweeping up the street.
As a last resort, after repeated long-term over-stimulation, the brain will shut down Dopamine receptors so that nothing can park there ever again. Think of this like the demolition team coming in and permanently barricading off the driveways.
This is your brain on Meth!
So now that we have a basic understanding of how things work normally, I'll try to explain how things work when meth is ingested.
When someone eats, snorts, injects, or otherwise gets meth into their system, meth stimulates those barrels of Dopamine to pour out Dopamine. Meth continues to tell the cells to pour out dopamine until the body can break down the meth, which is typically 12 hours or so.
So Dopamine is poured out into the synapse (street) and finds parking spaces at dopamine receptors and makes the user feel high.
But meth is a tricky little chemical. It is shaped closely enough to Dopamine that the tow trucks get confused, and pick up meth thinking that it is dopamine. So the tow trucks are busy driving around hijacked by meth molecules leaving the extra Dopamine molecules floating around in the street (synapse). Well... that means the toxic waste crew comes in and destroys that dopamine that did not get recycled. So for the 12 hours or so it takes for the body to break down the meth, it is also spending that time destroying dopamine.
As long as the user keeps ingesting more meth, this process continues until there is not enough dopamine left to feel high from. When the user finally stops using, and the brain breaks down the meth molecules, the recycle trucks try to salvage what dopamine there is left, while the user crashes.
The end result of a "run" or "binge" on meth is a marked decrease in the amount of dopamine left in the brain. This leaves the user feeling exhausted, hungry, depressed, possibly suicidal and definitely unmotivated. They are literally suffering from a brain chemical imbalance. Self-inflicted mental illness.
How can the brain ever be normal again?
Well, luckily, the human body is pretty resilient. We do have the ability to make replacement dopamine. However, the body was not designed to need to do this in large quantities or in quick supplies. So we don't have a mass-production plant making dopamine. It's a 3 to 4 step process, too.
The process: Phenylalanine --> Tyrosine -->L-dopa --> Dopamine
Phenylalanine is the first "pre-cursor". It can be found in the following foods: soybean protein, frozen tofu, dried and salted cod, shellfish, lean meat, organ meat, skin-free chicken, cheese, milk, eggs, many seeds (watermelon, fenugreek, roasted soybean nuts), and chocolate. Equal artificial sweetener also contains Phenylalanine. The body can turn Phenylalanine into Tyrosine.
Tyrosine can also be found in food. This would eliminate the need for the body to synthesize it from Phenylalanine. One step closer to dopamine! Meat, dairy, eggs as well as almonds, avocados and bananas are good sources of Tyrosine.
From there, the body will convert Tyrosine into L-Dopa, and then on to Dopamine (and other neurotransmitters like norepinephrine).
So... to replace dopamine destroyed while high on meth, the recovering user must eat sources of Phenylalanine or Tyrosine.
To aid the body in making Dopamine, the person can use what dopamine they DO have left as often as possible. This tells the body that they need more of it. While you sleep, you use very little dopamine. Exercising, even just a walk around the block will use dopamine (remember, it controls movement). So setting a reasonable sleep schedule, and trying to get some exercise will help speed up recovery from Self-inflicted Dopamine Destruction (aka meth addiction)!
Be patient -- remember, we weren't designed to waste dopamine, we were supposed to be recycling it. The process of replenishing dopamine takes months. Studies show that recovering meth addicts who have abstained from meth use have about 80% of normal dopamine levels after 18 months of abstinence. This WILL be a long battle. It CAN be won.
What about the receptors that were destroyed?
Well, good news again. Even though those receptors can never heal or recover, the brain is able to use existing receptors and find new pathways to accomplish the same results. Some receptors will even get a home equity loan and build on extra parking spaces!
Are there any medicines that can help?
A doctor should always be consulted and included on any medication treatment for a recovering user. Many recovering addicts have found Wellbutrin (Bupropion) to be helpful after a few months of clean time. What Wellbutrin does is block some (not all) of the tow trucks for a little while so that the dopamine the person has left can be more effective. It does not, however, stimulate the barrels to pour out dopamine. The person has to have enough dopamine in their brain before Wellbutrin can help.
Health stores do carry supplements of Phenylalanine and Tyrosine. A recovering addict who finds it difficult to eat enough protein may benefit from a supplement. Again -- consult your doctor first.
Lori Pate
B.A Psychology
University of Texas at Austin
Member
Join Date: Jul 2009
Location: Marshall, TX
Posts: 84
I do not know how to thank you enough. This really helped me understand some things that had puzzled me for quite some time.
It also helped ease one of my biggest fears about her future, which was if she did manage to stay clean, could her mind and body ever recover from the damage she had done?
I have seen my daughter get clean twice before and always wondered why I still saw her doing some of the strange things she did when using (i.e. one day she was going to microwave a sausage biscuit and instead of putting it in the microwave, she put it in the cabinet next to the microwave, then couldn't find it. I found it later when unloading the dishwasher. It's really funny now, but not so much at the time.).
I will keep this to read again when I start to feel fear or frustration when she's not progressing like I think she should. I promise to be patient with her. I love her very much.
This was a godsend. Thanks again!
It also helped ease one of my biggest fears about her future, which was if she did manage to stay clean, could her mind and body ever recover from the damage she had done?
I have seen my daughter get clean twice before and always wondered why I still saw her doing some of the strange things she did when using (i.e. one day she was going to microwave a sausage biscuit and instead of putting it in the microwave, she put it in the cabinet next to the microwave, then couldn't find it. I found it later when unloading the dishwasher. It's really funny now, but not so much at the time.).
I will keep this to read again when I start to feel fear or frustration when she's not progressing like I think she should. I promise to be patient with her. I love her very much.
This was a godsend. Thanks again!
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Thread Starter
Join Date: Feb 2008
Location: Kansas
Posts: 10,182
You're very welcome! I first got clean/sober back before all the research and so much was known about meth addiction. I did a 30 day in-patient rehab, and then was out on my own to raise a daughter by myself in a whole new place (I opted to move as my then husband was actively using/psychotic/violent).
Those first couple of years were really hard, and now a lot of that struggle (both physically and emotionally) makes sense when I see the research that has been done. I did a ton of meetings, had two sponsors, worked through those steps, and just kept putting one foot in front of the other. It seemed my emotions were pretty raw those first two years too.
It does take time, and I am also living proof that recovery is possible. I did relapse after 4 years because I had minimized my alcoholism and drank again. I spent 2 miserable out-of-control months out there, and then drug myself back up the steps of AA.
In 4 days I will celebrate 19 years clean/sober. Recovery is there for those who want it badly enough and will go to any lengths to maintain it.
I will keep you, your daughter, and that precious granddaughter in my prayers. :ghug2
Those first couple of years were really hard, and now a lot of that struggle (both physically and emotionally) makes sense when I see the research that has been done. I did a ton of meetings, had two sponsors, worked through those steps, and just kept putting one foot in front of the other. It seemed my emotions were pretty raw those first two years too.
It does take time, and I am also living proof that recovery is possible. I did relapse after 4 years because I had minimized my alcoholism and drank again. I spent 2 miserable out-of-control months out there, and then drug myself back up the steps of AA.
In 4 days I will celebrate 19 years clean/sober. Recovery is there for those who want it badly enough and will go to any lengths to maintain it.
I will keep you, your daughter, and that precious granddaughter in my prayers. :ghug2
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