entropy, one of the thoughts that came to me early-on in this is that in fact eventually humans will either self-destruct or be taken out by some Force of the Universe. I mean, of course the planet will be better off and will do just fine - unless it's blown up entirely somehow by some larger force like the sun imploding or a massive collision with some random space object.
The meek shall inherit the earth.
Nothing much smaller and less significant than a coronavirus.