My first year of menopause was Armageddon. I have never felt more exhausted or strung out...it's not a coincidence that was my last year of drinking. Something had to give...you're a step ahead on that score, so good for you!
I googled the side effects of Topomax and the first thing listed was tiredness.
Time to march back into your MD's office and get an evaluation, yes? You may be far more sensitive to meds right now because of the hormonal imbalance. I certainly was and have stayed that way...I always ask to start with a quarter dose of any new medication for that reason.
Sending you a hug!