There was a Radiolab episode last year about addiction called "The Fix." The first half of the episode discussed the effectiveness of such as naltrexone to address alcoholism. The second half of the episode focussed on one person who in the beginning seemed to benefit from the drug. However, he then went back to the bottle. He stopped taking the drug because he missed the feeling he had when he was drunk. He had spent so much of his life coping with his insecurity by drinking alcohol that when it was gone he didn't know how to cope. But he's trying to get back on the wagon. And he's back in AA.