I told her I was worried she was using alcohol as a crutch. She told me "If I were using it as a crutch, I would never be sober."
Your wife appears to be miserable, living in her own skin.
We could have the talk of what came first, the chicken or the egg, ( booze or depression/anxiety), but it would be fruitless as this is her issue, and hers alone to address.
So it there anything she is willing to do, to help herself ?
Sorry to say, there isn't much you can do for a person who will not acknowledge there is a problem.