Wow. the most I ever took, 50 10/325s in a day 12-14 at a time. I did that often from January to March until the doc cut me off. My cat accidentally bit me and I ended up almost losing my hand. I spent a week in the hospital and had two surgeries to save it. When I woke up from the first surgery the anesthesiologist was in my face saying "you take a lot at home don't you?" They had to give me so many drugs during surgery it suppressed my breathing. They had to keep waking me up and telling me to breathe. My oxygen stayed at 80 for two days!