Dar MJ, I have seen my son detox before and my biggest mistake was always tending to him. I believe he made it look/feel a lot worse because i was taking pity on him.They say the worst peak is at 72 hours. The initial signs of detox include massive sweating, pin ***** pupils, yawning, vomiting. The shakes, the chills, the restless legs and the agitation start after 48 hours. After 5 days or so, they start to get human again.