i was diagnosised manic depressant when i was 16 they tried alot of drugs on me. but a word of caution if you are prescribed anti-depressants and you bi-polar they can send you into a major manic episode it took them years to figure that one out,but this is what worked for me seroquel and yes when you first start taking it you will feel messed up but after a week or so it levels out you body gets use to it, neurontin also worked for me. depokote is a great drug but can cause weight gain but has low side effect. with neurontin and seroquel they dont need to monitor your levels which is anoter good thing