When I had a nervous breakdown noone was able to help me. I was put on zoloft but it made me not feel so I stopped taking it and in a short time had intense depression withdrawals and tried to commit suicide. After some more drinking and rehabs I stopped drinking and was stuck taking benzos, coping with intense anxiety. After some years of that I manged to reduce benzo intake to zero. Ultimately what has made a difference is meditation while learning that the 'I-making' of every 'thing' and 'thought' is at the core of my miseries. Letting go in all ways (while trying to have compassion for all beings) has helped me to find a lasting, meaningful, serenity. Part of that has been recognising the ever-changing, not-me nature of every thing (and thought) that passes by.