I know this will sound crazy but my very best friend on this earth passed from liver failure in 2003. She did not see the color change. She had no idea that her beautiful blue eyes looked like they were swimming in yellow food coloring. She started vomiting blood one day and 28 days later, she was gone. She was 2 weeks sober when she collapsed in her bathroom. She had filed for divorce form her abusive husband, gotten a new job and was about to move into her own apartment...she didn't believe that alcohol could be killing her if she wasn't drinking it but the damage was done. She was 43.
I remember the color more than anything else...her blue, blue eyes.
If you are open to it, I agree with the others that commenting on it cannot hurt. Have the courage for him where he cannot find it for himself. If he gets mad about it, so be it. At least you can live with yourself.