Not sure what you’re referring to in terms of end stage alcoholism, but I’m a nurse and I have seen people with long term alcoholism die from the complications of alcoholism such as cirrhosis and as a gauge of the seriousness we look at liver function tests, ammonia levels, kidney function, as cites, and blood clotting parameters to name a few. I have seen those who suffer from Wernicke’s encephalopathy and I have seen some die from fulminating pancreatitis and sepsis. Another, often forgotten symptom....traumatic injury around circumstances when alcohol i used! This is what I always thought of as end stage. Important to note though that alcohol cessation at any stage and even with organ failure can be life saving and well worth it.