Originally Posted by
least 
I've been on sertraline (zoloft) for the last twenty years. When I was drinking, they did no good at all. After I got sober for good, the meds worked as they should.
This was my experience as well. Drinking alcoholically will cancel out the antidepressants, because of the effect large amounts of alcohol has on the brain. I know mine stopped working as soon as I started drinking too much.