In terms of "cards left to play," if you mean trying to do something that you, personally, can do to get her to change, I think there aren't any. There aren't even if you hadn't stayed with her all these years and done everything you can think of. You aren't overlooking some magical THING that would make a difference.
In terms of being a decent and loving husband, it sounds like you have been. That you resign from the job of watching her destroy herself doesn't mean you have done anything unreasonable, unfair, or cruel. YOUR life and happiness count, too. Hers is (and has been) in her hands. Yours is in yours.