Drinking while taking antidepressants isn't a good idea - as noted above, the alcohol (a depressant) will negate the anti- effect of the drug. What you're seeing (what she is experiencing) may well be the antidepressants finally kicking in (it takes a week or so for them to take effect) - they can dull the emotions somewhat (depending on the dose) which may be what she is feeling. Of course, if she is an alcoholic, she won't see the drink being part of the problem :-( but search around for something (or someone) to blame the feelings on