I have been on Zoloft for about a year. I went to the doc on Friday because I was wondering if maybe My weight gain (25lbs in one year!!!!) was the cause of it. She changed me to Lexapro. I have only taken 2, so I don't know what the outcome of that will be. I know with the Zoloft, it was a life saver to me! I didn't have that "down in the hole" feeling! It never occured to me that the zoloft may be causing my weight gain. I don't know if that is the reason, but I will soon find out! Talk to your doctor. Good luck!