I took beta blockers for years to help with public speaking; they suppress your "fight or flight" response, and you feel calm - hands steady, voice OK - even if you're terrified or excited or angry or whatever. I drank a great deal after taking them without noticing that they combined with alcohol in any way. Their biggest contraindication is asthma, which I have, and have had pretty bad attacks when I've forgotten that I'd taken them and then exercised.