If you have a possible mood disorder, be veeery careful and aware while taking ADs. They can shoot you in to a manic state if used without a stabilizer and it's scary. That's how I found out I was bipolar. Otherwise, you probably won't see a difference for a couple weeks, or until your dosage changes. Side effects vary for everyone and I've never taken Cymbalta so I can't help there. Unfortunately often the only way to figure this stuff out is by trial and error, guinea pigging you with different medication and seeing how you react to it.