Sometimes we find it's not that we are not comfortable with our lives (spouses, job, finances) it's that we are not comfortable in our own skin. So we seek to self medicate, escape, etc.
We have all the outer earmarks of happiness and success but inside something is missing or not right.
I discovered what that something was, and how I could address it through spiritual and 12 step programs. There are other means as well.
Ha ha, now my outside situation is pretty crazy, but my inside situation is pretty OK, and I haven't relapsed for a long time. Go figure!