Definitely disorienting doing things sober the first time (since we were kids anyway). I've felt that way enough times now to kind of feel curiously amused now instead of worried, though. As in, "I wonder what it will be like to sit in the bleachers at Wrigley sober?"
I remember being pretty worried about holidays & bday parties & such, but they were a lot easier than I thought they'd be, and once people started getting too loopy, I just went home thinking, "Thank God that's not me again."