seroquel, UGGG! What to say here... For me, seroquel worked for my insomnia for about 45 days and then it turned my sleep into a nightmare. It gave me severe RLS! To the point my wife finally kicked me out of bed. I ended up going on trazadone which has worked MUCH better! I'm not groggy in the morning any more, I didn't gain the weight like I did on seroquel either.