Everyone's system reacts differently so it's hard to say (withdrawals) but I watched my ex go through 2 detoxes (one at his Mom's and one at our place) and one "smaller" one only because he ran out of his script once before he had his next doctor's appt. And among many other natural remedies, B6 or a multi B vitamin was one of the things he took to help him through his withdrawals. Throwing up, shaking, runny nose or stuffy nose (mimics allergies), lack of appetite, etc. He found it hard to sleep too.