I have had a seizure condition (due to head injury) for past 6 years.. I have had seizures in the past while doing or being around COCAINE and OXYCONTIN. But its been about 8 months since i had a seizure, due to DEHYDRATION. i take daily meds for that condition. I dont and have never been really fond of drinking alcohol- just filled in that void with marijuana. I have been banging up for about 3 months now. As far as mixing uppers and downers-- I DONT DO THAT. I have never liked Xanax. I also heard ALOT of ppl OD and die over doing ROXIES or PAIN PILLS, then taking a xanax or two to get sleep.. THIS IS VERY HARD FOR ME THOUGH!