IMO he should see a doctor.. It doesnt sound like it has anything to do with the Sub but 1 thing you could try if he's only dosing with the Sub once per day is to make sure he takes his daily dose before noon everyday.. some people have trouble sleeping if taken any later. If that doesnt make a difference then he should see a doctor about possibly needing some type of sleep med and to rule out other serious problems, im leaning more towards he needs to see a doctor though, Ive only heard of people having trouble falling asleep if they take their Sub later then noon, I've never heard of not being able to sleep at all.. def. get him to bring this problem up with his Sub doctor ASAP, sleep deprivation is NOT healthy and could cause alot of serious problems. Good Luck & I hope he gets better soon!