View Single Post
Old 09-01-2011, 07:01 PM
  # 23 (permalink)  
FT
Member
 
Join Date: Dec 2010
Posts: 3,677
A word about Antabuse

Disulfiram (Antabuse) is an aversion-based treatment that acts by blocking aldehyde dehydrogenase (ALDH). When taken in the presence of alcohol, ALDH levels spike, which causes severe dizziness, flushing, nausea, vomiting, low blood pressure, irregular heartbeat, possible convulsions, depressed breathing, and has even known to induce a heart attack.

Disulfiram in the absence of alcohol tends to cause minimal effects; however, drowsiness, metallic aftertaste, and liver toxicity may occur. Antabuse can't even be started until the you have abstained from alcohol for at least 12 hours. In addition the ALDH effect is irreversible, so alcohol consumption must be avoided for 2 weeks after the last dose.

This is a serious drug, folks. Not one I would want to ingest, nor anyone I cared a whit about.

I didn't make this stuff up. You can read this for yourself here:

Krina H. Patel, PharmD. "Pharmacologic Management of Alcohol Dependence: Pharmacologic Therapy" US Pharmacist. 2009;34(11):1-4. © 2009.
FT is offline