I've met a couple of people with TS, but didn't know them well, definitely not enough to know the extent of any accompanying ADD or OCD. One I met through work, and she seemed pretty comfortable in her skin. The other I knew through family friends, and he struck me as very withdrawn the couple times I saw him.
I can only tell you that I don't see it as a joke, and I have infinitely more respect for someone who lives with it than someone who laughs at it. Compassion, admiration—I like to think that's what most people feel when they see someone else dealing with adversity.