i think the reality is you have an illness and it takes sometimes different approaches to medication and other means to find what works for you...i feel lucky enough to find desvenlafaxine and lithium help stabilise my mood, however i have increased the dose with my doctor in the past and will ask again this week as ive felt myself sinking a bit the last few weeks...do what i think is best but try to always ask doctor first, not just random experimentation or "think" i know whats best. stinking thinking