I've been on zoloft (sertraline) for over ten years and never gained weight, I lost weight, which for me is not good. It took care of the depression tho and gave me incredible energy. Go figure... I think it's just different for different people and depends on individual metabolism too. Maybe why some lose weight and some gain. I'd ask your doctor to try you on something else, there's a lot out there, until you find what's right for you. Best of luck to you.