I started taking suboxone when I was out of detox 7 days. I had been on a methadone clinic for a long time. I started to feel better from the withdrawal symptoms within 15 to 30 minutes after I took them. I mean, I stopped trembling and twitching and shaking. As far as the long term benefits I've only been on them a short time after a relape. I do know if you take them too soon after opiates/opioids you get ill. It's not very nice. Shivers and chills etc. I think it's best to take them "Only as directed" by your physician.