There's different detox programs, some medical like suboxone detox for 1 - 2 weeks, some taper you off. Please take her to her doctor, and let him/her decide when she's able to detox and hat program. I can certainly understand her desire to detox NOW, because she is having some organ damage from the Vicodan. Did you know that with Vicodan abuse, its the TYLENOL part that will do damage before the codeine part? My SIL is an opiate painkiller addict too, has been for at least 6 years. Currently clean. Can you ask her doctor to prescribe something w/o the tylenol until rehab time? (Hope this isnt considered medical advice!!) Again, please take your wife to the doctor about when and what kind of detox is advisable in her situation.