I've been on antidepressants for over ten years now. I noticed that when I was drinking my depression got worse, perhaps cause alcohol is a depressant and so antidepressants don't work as well. I'm sober for 73 days now and am noticing my antidepressant is working better. I'll probably be on antidepressants the rest of my life, but as long as I'm not drinking, they will be a lot of help for me in dealing with this severe depression.