An interesting topic.
IMHO, it will still be a long time before we have any conclusive evidence as to what makes the alcoholic. There are many that schools of belief on the subject. My thought is since there appears to be a genetic aspect to alcoholism (at least it appears to be true of many) that the difference starts out as a physiological problem which turns into a psychological and spiritual one as we progress in life and our disease. But that is just my theory and thoughts. No way for me to prove or disprove it.