NYC: Maybe a trip to the doctor is in order. Weight loss, anxiety, panic attacks, and inability to sleep are symptoms of an overactive thyroid. So is paranoia (thoughts that you/your work are not good enough, that people don't like you, that folks are out to get you, etc.). Beta blockers are used to treat the symptoms of hyperactive thyroidism, as are anti-thyroid drugs.
Sometimes the cause of distress is not emotional, but physical.