Physical dependence is a killer on your drinking lifestyle. The depression alone brought on by physical dependence was unbearable for me. Hands a shaking, anxiety, hungover or tired all the time, no desire for food & sweating like a maniac. It sucks to drink into physical dependence. What a frickin nightmare...having to drink even when I didn't want to...as far as low self esteem & depression, alcohol won't help with that either. Oh, the woes!