This is just my opinion. Some depression is chemically based. Some depression is situational. I think far too many people try to medicate themselves out of situational depression. The medicine would respond of the problem were chemical. The medicine wouldn't work if the depression is situational. You may have to try a few medications to find the right one. You've done that. Maybe it's time to try changing the situation. You can take enough meds to sit in a drooling heap but there is no quality of life doing that. Depression is anger. I would imagine living in a bad situation that doesn't change would make a person angry. Then more angry. Then more angry. Depressed, more depressed and more depressed. Changing the situation and taking power over your life might ease the depression.