I've been on Elavil, Prozac, Paxil, Zoloft, and Wellbutrin XL (time-released). The Wellbutrin is my latest try and it is the one that has had the least side effects for me.
The Wellbutrin helped to some extent when I started on it in '03, but my psychiatrist told me that it wouldn't matter if I take it or not at this point because I've been diagnosed with "severe" depression. I don't know if it's any more severe or not, but I do know that when I stopped taking the medication for a week, it did not make one bit of difference. I stopped taking it one other time, and I DID notice a difference within 5 days. I noticed feeling depressed. Not so, this go 'round.
I guess the bottom line is that no matter who you are, living with an A is similar to the progression of their disease; we get worse the longer we're exposed to their disease just like them.