Norcos have 10mg of Hydro-codone while Vicodin 750's only have 7.5 mg. The difference is that the amount of Hydro is 10 instead of 7.5 and the Tylenol is only 325mg for the Norcos instead of 750mg in your 750 Vics'. I have been on this for 7 years, the last 3 at around 8 to 10 Norcos a day, or 20-25 Vicodin 5/500's. The usual story I'm sure......hurt my back at work, 1/2 healed went back to work only to re-injure and back on Opiates ever since. All history as I have a new job and my back pain isn't an issue. Soon....hopefully, neither will these dang pills!