Originally Posted by
MindfulMan 
TBPO I'm pretty indifferent to the tense used.
Past: In my case, x y and z interacted with substance use - sounds like its over.
Present: In my case, x y and z interact with substance use. - sounds like its not over.
Future: In my case, x y and z will interact with substance use. - definitely sounds like its not over. And it also brings in that so important word “will” that has more than one meaning. “choose to”, and “am going to”