There is research going on that indicates alcoholics have dopamine issues. Either we don't produce enough of it naturally, or we can't uptake it effectively. Thus, we turn to drinking to self medicate ourselves. Wellbutrin helping with dopamine uptake would make sense in that it would lessen cravings. As folks have said, brain chemistry is poorly understood, but I feel that down the line, the correlation between dopamine levels in our brains and alcoholism will be better established.