I think for many this is the point when the light bulb comes on that it's time to hang up the booze. Hangovers that went from mild annoyances for maybe just the next morning, to crippling hell that can last for days. Continuing to try and fight with the booze, but you keep losing over and over and over until the realization hits that no matter what you do, if you keep playing with it, the battle is lost, with the only way to win is to quit.