I tried Milk THistle and I was extremely itchy.. Turns out if you are at all allergic to ragweed it is not a good idea since ragweed one of the main ingredients. But I know others who have taken it and it was good for cleansing. I think that good clean eating is the best choice at first and then the cleanses. However that being said I decided to do a colon cleanse last week and it was really inexpensive. Nothing notable happened in the TMI department except two things. I had more energy and didn't eat as much as I usually do. I would recommend it.