I've never accepted the idea of a predetermined reality, partly because of quantum mechanics and partly because the idea of my life being planned out is simply awful. It would also take away responsibility for wrong doing, I mean if a serial killers life is planned then we can't blame them for their actions, that isn't right to me.
I mean if something random happens and I get killed I consider that bad luck rather than fate. But I know there are entire philosohy books about this very thing.