i've just been adjusted up from 300mg to 400mg nightly. the soporific effect seems to wear off after a while, and my psych is happier increasing the seroquel than prescribing benzos.
as for the weight gain - i gained 30 pounds in 3 months. now i'm sober i'm starting a real effort to drop that weight and more besides.
for me, however, the benefits outweigh the problems. my effexor and seroquel keep me alive. better that than skinny and suicidal.