One of the best treatments for depression is aerobic exercise - lace up those shoes. The second is self-talk and working on reframing our experience. I was a mental health professional and drugs keep the brain from recovery. We now know that even psyche drugs do this.
More than anything we need people under each arm dragging our ass to the other side - then we can drag another person to the light.
Don’t use a negative fix for a problem that has many healthy solutions