Even though, everyone says to drop it and leave her alone, i think talking to her "once more" will put YOU at ease. As a loved one, you want to help her and try to do something and when it doesn't work you feel helpless but in this case it seems you still have that little bit of hope. Dont get too emotionally involved when you do speak to her, because if nothing changes it will hurt you even more, but then you know you did everything you can!! Thats just my personality, I try EVERYTHING, and if in the end it doesn't work, i say i tried my best.
best of luck
take care of yourself