I think the hardest drug to come off would be the last one you choose to give up
In hindsight, alcohol was easiest for me - I just smoked more weed, cigarettes and ate more.
Weed was harder, but I smoked more cigarettes, popped the odd benzo (3-4 15mg serapax per week), and compulsively exercised.
I guess im hooked on pills now - but not one in particular. I take a mix of seroquel, serapax, (both prescribed) and herbal remedies, and I still smoke cigarettes. I dont intend to replace pills and cigarettes with anything, theyre gonna be with me for life