As her disease progresses one thing you may notice is either an increase or a decrease in her tolerance. I have a friend who has drank heavily for 30 years (and yes, I am very concerned for her) and I recently noticed that only after 2 glasses of wine she is very drunk. I was perpelexed by this until I read in Under The Influence that it is because her liver is not functioning as well as it used to and she's not able to metabolize the alcohol as efficiently as before. Scary. But as Lexie said, for your wife this could happen next week or next decade.... <shrug>