I was diagnosed with depression when my first marriage was falling apart, (well duh) and was prescribed wellbutrin. That was when I realized that my crappy marriage was bad for my health and instead of taking ADs I gave up on saving my crappy marriage. I felt much better after letting go of that crappy marriage. Years later during a particularly stressful time at home and work, during a routine physical I mentioned in passing the stress I was under and my GP wrote out a prescription for something without batting an eye, I forget what it was. I never filled that perp and got another job instead. The next time I was depressed was when my second marriage was falling apart. I didn't even bother getting a perp I would never fill. I knew what I had to do so I let my marriage go instead. In my case I didn't need them but they did serve the purpose of being a wake up call that I need to point my a$$ in healthier direction.