There are two things that are common in addictive drugs. Initially they produce a pleasurable effect, followed by a rebound unpleasant effect. Through its stimulant effects, an amphetamine produces a positive feeling, but when it wears off it leaves a person with the conflicting feelings. This is because of the suppression by the drug of the normal production of adrenaline. Now, a chemical imbalance is created and the result is irritability that physically demands more of the drug to go back to normal and feel good again. This pleasure/tension cycle leads to loss of control over amphetamines--and addiction.Amphetamine causes strokes, heart attacks
These brain cells represent a simplified way of looking at the BRAIN'S REWARD SYSTEM On the left we see the various drives and needs of the body; sex, hunger, thirst and friendship. When these drives are satisfied, or when pain is relieved, a signal is sent to certain brain cells (the monitor cell on the left) which manufacture a chemical substance that signals reward. When these monitor cells have been stimulated, a signal is sent to the tip where a small amount of this reward chemical is released. The chemical or neurotransmitter then reaches and stimulates the reward center, causing a feeling of well-being.
Amphetamine damages blood vessels
Amphetamines produce an artificial feeling of pleasure. Most addictive drugs are able to produce pleasurable effects by chemically mimicking certain normal brain messenger chemicals which produce positive feelings in response to signals from the brain. An example of this is the narcotic drug which mimics endorphin (nature's natural pain reliever). This is like having counterfeit money which will fit into the slot machine. When the drug comes in, its stimulates the reward center. This short circuits the survival mechanism, because the reward center cell can't tell the difference between the drug and the natural chemical messenger. The result is a dependence on the immediate, fast, predictable drug which, at the same time, short circuits interests in and the motivation to make life's normal rewards work.
Amphetamine causes addiction
When the amphetamine molecule comes in through the blood stream, it bypasses the natural nerve cells and causes the artificial release of normal, chemical messengers for positive feelings. What happens as a result of this is a feeling of satisfaction, well-being and relief. Then, automatically the system sends a signal of positive rewards back to the memory of this activity. The first of many pleasure hooks has been implanted into the memory. The amphetamine drug lies to both the Reward Center and to the Monitor Cell. To maintain a balance the cell settle in the surplus stimulating effect of amphetamine by closing down the production of the natural stimulatory chemistry.