APAP side effects

[igetallnumb]

Using is bad enough and this is for all the current and past users of Vic's (Hydrocodone APAP) as you know the acetaminophen count is very high (usually 750 mgs per dose) and very harmful to the liver is high doses. Which for abusers you are well over 3000 mgs by nightfall
My question to everyone who has abused this is ... do you feel besides withdrawal other feelings associated with the liver? (skin tint slightly yellowing , extreme fatigue, difficulty with using the loo (bathroom) etc)

[StagebearNJ]

If you are experiencing any symptom that might indicate problems with liver function, please get medcial attention right away.
Symptoms such as jaundice (yellowish hue), etc are never to be taken lightly, nor should you look here for reliable diagnoses or treatment suggestions.
Overdose of acetaminophen (a.k.a. APAP, Tylenol) are a very real risk with abuse of hydrocodone combos and have caused some serious damage.
Likely you will get through it and I am not trying to scare you. See a medical professional as soon as you possibly can.

Best,
Bear

[igetallnumb]

Originally Posted by StagebearNJ

If you are experiencing any symptom that might indicate problems with liver function, please get medcial attention right away.
Symptoms such as jaundice (yellowish hue), etc are never to be taken lightly, nor should you look here for reliable diagnoses or treatment suggestions.
Overdose of acetaminophen (a.k.a. APAP, Tylenol) are a very real risk with abuse of hydrocodone combos and have caused some serious damage.
Likely you will get through it and I am not trying to scare you. See a medical professional as soon as you possibly can.

Best,
Bear

seeing my doc tomorrow bear
Oh i wasn't looking for a DX I was just looking to see if others share my experience
thank you

[baggervance]

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[igetallnumb]

Originally Posted by baggervance

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[Aducksdelight]

I started off on Vicodin and moved to Oxys. I was doing well over 3000mg APAP a night and I wondered about liver function as well. Wondered--but didn't stop. I don't know what kind of damage I have done to my body but I haven't experienced any jaundice or lethargy (not more than the usual) and trouble going to the loo (which I love to say seeing as I am from California lol).

[Buzz Kilowatt]

People metabolize APAP differently, it seems.

Normally, the liver turns the APAP and its metabolites into harmless chemicals that are excreted from the body. However, if the liver is overwhelmed, a toxic chemical is produced (abbreviated NAPQI), which kills liver cells.

Much of the liver's ability to metabolize APA depends upon the store of a chemical called L-glutatione, which binds to the toxic NAPQI so that the body can get rid of it. Alcohol competes for the same L-glutatione; that's why it is especially dangerous to drink while taking APAP.

Other things affect the store of L-glutatione, such as fasting, which depletes it.

N-acetyl-cysteine (NAC) is the antidote that emergency rooms administer for acute APAP overdose. If administered quickly after ingestion, the prospects are good. The NAC works by increasing the bioavailabilty of the L-glutatione.

Some people who take APAP regularly also take NAC supplements, which are available over the counter, to lessen the toxicity of the APAP. Milk thistle is also touted by some as a good supplement for liver detox.

Symptoms of liver malfunction may include: yellowish skin and sclera (whites of the eyes); light-colored, loose stools w/ dark-colored urine; fatigue; nausea; pain in the upper right abdominal quadrant; skin rashes & itching, etc.

If you are experiencing any of those symptoms (and I inferred from your post that you are) it is essential to visit a doctor who can do a liver panel to check for proper liver function. They will likely draw a small amount of blood and maybe urine.

There are other causes of these symptoms in addition to chronic or acute APAP ingestion, such as pancreatic or gall bladder problems; hepatitis; drug reactions and interactions, etc.

It is important to rule out anything of concern. Don't delay a visit to your MD to allay your concerns.

Best regards,

Buzz

[igetallnumb]

Originally Posted by Buzz Kilowatt

People metabolize APAP differently, it seems.

Normally, the liver turns the APAP and its metabolites into harmless chemicals that are excreted from the body. However, if the liver is overwhelmed, a toxic chemical is produced (abbreviated NAPQI), which kills liver cells.

Much of the liver's ability to metabolize APA depends upon the store of a chemical called L-glutatione, which binds to the toxic NAPQI so that the body can get rid of it. Alcohol competes for the same L-glutatione; that's why it is especially dangerous to drink while taking APAP.

Other things affect the store of L-glutatione, such as fasting, which depletes it.

N-acetyl-cysteine (NAC) is the antidote that emergency rooms administer for acute APAP overdose. If administered quickly after ingestion, the prospects are good. The NAC works by increasing the bioavailabilty of the L-glutatione.

Some people who take APAP regularly also take NAC supplements, which are available over the counter, to lessen the toxicity of the APAP. Milk thistle is also touted by some as a good supplement for liver detox.

Symptoms of liver malfunction may include: yellowish skin and sclera (whites of the eyes); light-colored, loose stools w/ dark-colored urine; fatigue; nausea; pain in the upper right abdominal quadrant; skin rashes & itching, etc.

If you are experiencing any of those symptoms (and I inferred from your post that you are) it is essential to visit a doctor who can do a liver panel to check for proper liver function. They will likely draw a small amount of blood and maybe urine.

There are other causes of these symptoms in addition to chronic or acute APAP ingestion, such as pancreatic or gall bladder problems; hepatitis; drug reactions and interactions, etc.

It is important to rule out anything of concern. Don't delay a visit to your MD to allay your concerns.

Best regards,

Buzz

My psych background doesnt cover the liver lol
thank you ever so much ... My doc took a liver panel on me today so he can figure out whats the deal with it.
Ive had stones in the past in my kidneys so ... my renal functioning is not so great (due to drugs i would say yes)
so fingers crossed we will see

[emmer]

Yep, my skin went yellow twice while abusing handfuls of t1's.