Ketamine for Depression
Sobriety is Traditional
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Join Date: Dec 2012
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Ketamine for Depression
"Recent studies report what is arguably the most important discovery (for depression) in half a century: the therapeutic agent ketamine that produces rapid (within hours) antidepressant actions in treatment-resistant patients."
Ronald S. Duman and George K. Agkhajanian (Yale University), "Synaptic Dysfunction in Depression: Potential Therapeutic Targets," Science vol. 338, 5 October 2012, p.68.
I guess this is known as "Vitamin K" on the street... anybody know anything? I trust your advice more than just googling it.
Ronald S. Duman and George K. Agkhajanian (Yale University), "Synaptic Dysfunction in Depression: Potential Therapeutic Targets," Science vol. 338, 5 October 2012, p.68.
I guess this is known as "Vitamin K" on the street... anybody know anything? I trust your advice more than just googling it.
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Join Date: Jan 2013
Location: Bath
Posts: 9
Ketamine did wonders for my depression but I'd be hesitant to believe the hype, it was the same as most drugs are for us - they do help us immensely in terms of coping but also send us into horrible lows.
I found ketamine ultimately had similar traits to weed and alcohol in that they would make me forget about my associations with reality, and nothing does that much better than a k-hole.
I know people that say that it has changed them for the better and others that say it has ruined them, I'd love to give an answer that could help you but at the end of the day ketamine is a drug that effects your brain like any other and how you react to it is different in everyone.
One thing I would say however is that you can feel very dark about yourself on ketamine. When I was k-holing once I believed I was dead, it's a fairly common experience for k users and you genuinely do "see the lights" and all that. Some people describe it as cleansing but it just made me reflect on where I was in life and that if I was dead, why should anybody care?
I can safely say that experience did nothing good for me whatsoever.
I found ketamine ultimately had similar traits to weed and alcohol in that they would make me forget about my associations with reality, and nothing does that much better than a k-hole.
I know people that say that it has changed them for the better and others that say it has ruined them, I'd love to give an answer that could help you but at the end of the day ketamine is a drug that effects your brain like any other and how you react to it is different in everyone.
One thing I would say however is that you can feel very dark about yourself on ketamine. When I was k-holing once I believed I was dead, it's a fairly common experience for k users and you genuinely do "see the lights" and all that. Some people describe it as cleansing but it just made me reflect on where I was in life and that if I was dead, why should anybody care?
I can safely say that experience did nothing good for me whatsoever.
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Originally Posted by Coldfusion 
"Recent studies report ketamine produces rapid (within hours) antidepressant actions in treatment-resistant patients."
Science vol. 338, 5 October 2012.
Science vol. 338, 5 October 2012.
I won't touch the stuff.
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Apparently, there are some new studies trying to use ketamine for depression:
BBC News - Ketamine 'exciting' depression therapy
BBC News - Ketamine 'exciting' depression therapy
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Join Date: Nov 2013
Posts: 117
I think LSD and magic mushrooms have potential benefits for consenting adults who understand the risks but we have this 'war on drugs' thing going on so researchers are not allowed to mess with the stuff. Meanwhile it's "O.K" for the pharma companies to test Paxil on 7 year olds !
About 130 children have been enrolled, according to ClinicalTrials.gov, which puts about 65 patients in each arm. That means the results won't be too statistically robust -- there only need to be two or three outlier results to skew the numbers by several percentage points.
Read more if you want, ww.cbsnews.com/news/glaxo-is-testing-paxil-on-7-year-olds-despite-well-known-suicide-risks/
About 130 children have been enrolled, according to ClinicalTrials.gov, which puts about 65 patients in each arm. That means the results won't be too statistically robust -- there only need to be two or three outlier results to skew the numbers by several percentage points.
Read more if you want, ww.cbsnews.com/news/glaxo-is-testing-paxil-on-7-year-olds-despite-well-known-suicide-risks/
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Join Date: Oct 2012
Location: Orion spur of the Milky Way galaxy
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Originally Posted by HJIK
I think LSD and magic mushrooms have potential benefits for consenting adults who understand the risks but we have this 'war on drugs' thing going on so researchers are not allowed to mess with the stuff. Meanwhile it's "O.K" for the pharma companies to test Paxil on 7 year olds !
About 130 children have been enrolled, according to ClinicalTrials.gov, which puts about 65 patients in each arm. That means the results won't be too statistically robust -- there only need to be two or three outlier results to skew the numbers by several percentage points.
Read more if you want, ww.cbsnews.com/news/glaxo-is-testing-paxil-on-7-year-olds-despite-well-known-suicide-risks/
About 130 children have been enrolled, according to ClinicalTrials.gov, which puts about 65 patients in each arm. That means the results won't be too statistically robust -- there only need to be two or three outlier results to skew the numbers by several percentage points.
Read more if you want, ww.cbsnews.com/news/glaxo-is-testing-paxil-on-7-year-olds-despite-well-known-suicide-risks/
Night owl
Join Date: Oct 2012
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When I first heard about ketamine for depression I was deeply skeptical. Then I saw a special on the recreational use of ketamine and I admit the addict in me was intrigued. The chance to just disappear for awhile, k-hole, and of course used IV (my favorite route of administration) also appealed. Along with that--and part of the addiction--is the fact that I am one of those people with multiple years of unhealed depression. And the desperate and hopeful parts of me would try just about anything to cure it. Especially this latest very severe bout.
If it could truly alter the brain that much, it would be a miracle. Even if some very small level of repeated dosing were necessary that would still be an improvement over much of what's available. I would probably enroll in a trial if there were one, or at least I would consider it and discuss it with my doctor. But I also wonder what danger there may be for a recovering addict to do this, if any? And what could be done to protect the urinary system because ketamine can destroy it.
I wish we could end this war on drug addicts (as I call it) and replace it with true science, common sense and a whole world of compassion.
If it could truly alter the brain that much, it would be a miracle. Even if some very small level of repeated dosing were necessary that would still be an improvement over much of what's available. I would probably enroll in a trial if there were one, or at least I would consider it and discuss it with my doctor. But I also wonder what danger there may be for a recovering addict to do this, if any? And what could be done to protect the urinary system because ketamine can destroy it.
I wish we could end this war on drug addicts (as I call it) and replace it with true science, common sense and a whole world of compassion.
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Join Date: Apr 2014
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the only thing ketamine ever did for me was make me sleep... zonk me out flat in a matter of minutes of taking it @_@ but then, speed does that to me as well..others are bouncing off the walls and im happily tucked under a blanket getting some sleep.. weird i know
i found that mdma really DID help with all sorts of my problems like my ptsd, social anxiety and i was really interested in the study that was televised over here in the uk last year. I wholeheartedly agree and i wish they would hurry these clinical trials up. I mean i like my E just fine as it is, but it really does make me feel better for a few weeks after and i find that i can relate to people, am less anxious etc. for a good 3 weeks or so after taking pills.
It is like ritalin (speed) for adhd... eventually scientists will hopefully find a therapeutic dose and it will transform so many lives.
i found that mdma really DID help with all sorts of my problems like my ptsd, social anxiety and i was really interested in the study that was televised over here in the uk last year. I wholeheartedly agree and i wish they would hurry these clinical trials up. I mean i like my E just fine as it is, but it really does make me feel better for a few weeks after and i find that i can relate to people, am less anxious etc. for a good 3 weeks or so after taking pills.
It is like ritalin (speed) for adhd... eventually scientists will hopefully find a therapeutic dose and it will transform so many lives.
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Join Date: Mar 2014
Location: Los Angeles
Posts: 3
Ketamine, the animal tranquilizer?
I'm pretty sure that's what we're talking about. I've bought it, cooked it, sold it.
It feels like being drunk without drinking. It's a huge body high.
After doing a lot of it, you'll start to have mild hallucinations , I remember very very vividly that I was floating in the ocean, hearing calming music and speaking with god, when really I was lying on a small mat in a quiet and dark apartment.
It was a trip to use and abuse.... Because it is a drug, used to sedate animals, from animals as small as cats to as large as elephants.
I wouldn't recommend it to anyone who is trying to find happiness within "this reality"
Being in a K-hole is being way way far away from reality. You'd be building a castle out of clouds, and any enjoyment or relief from it would be extremely temporary.
That's just my experience, though.
I'm pretty sure that's what we're talking about. I've bought it, cooked it, sold it.
It feels like being drunk without drinking. It's a huge body high.
After doing a lot of it, you'll start to have mild hallucinations , I remember very very vividly that I was floating in the ocean, hearing calming music and speaking with god, when really I was lying on a small mat in a quiet and dark apartment.
It was a trip to use and abuse.... Because it is a drug, used to sedate animals, from animals as small as cats to as large as elephants.
I wouldn't recommend it to anyone who is trying to find happiness within "this reality"
Being in a K-hole is being way way far away from reality. You'd be building a castle out of clouds, and any enjoyment or relief from it would be extremely temporary.
That's just my experience, though.
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Join Date: Dec 2013
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LOL, I have done more than my far share of Special K as we called it, and there is nothing like a K-Hole for getting you out of a funk, but the come down off it is crazy intense depending on the dosage. I can see how in small doses it could help with extreme cases of depression talking about extreme somthing is better than nothing cases of depression, but with the way some docs write scribs for antidepressiants I would hate to think that Ketamine would become a staple med for your run of the mill depression.
Thats just this former Rx loving pill popping party drug users 2 cents though.
Thats just this former Rx loving pill popping party drug users 2 cents though.
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More news about ketamine. Apparently now it has been found that one of ketamine's metabolites has the antidepressant effect, and maybe this can be isolated.
'Club Drug' Ketamine Rescues Suicidal Patients: Study - NBC News
'Club Drug' Ketamine Rescues Suicidal Patients: Study - NBC News
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Join Date: Dec 2015
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There is ongoing research with using psychedelics to treat depression and anxiety. The results so far have been nothing short of astounding. Just do a Google search for "magic mushrooms for depression" and you get tons of recent articles. Here's just one recent article on the subject from Time Magazine:
Magic Mushrooms for Depression: New Study Shows Promising Results
Ayahuasca is another powerful psychedelic that does an amazing job of clearing depression and anxiety on a long-term basis. I have personal experience with ayahuasca, and have used it one time. The ayahuasca experience can be extremely difficult, however. It was probably the most intense thing I've ever experienced in my life. But it did dramatically reduce my depression symptoms.
Ayahuasca Psychedelic Tested for Depression - Scientific American
Magic Mushrooms for Depression: New Study Shows Promising Results
Ayahuasca is another powerful psychedelic that does an amazing job of clearing depression and anxiety on a long-term basis. I have personal experience with ayahuasca, and have used it one time. The ayahuasca experience can be extremely difficult, however. It was probably the most intense thing I've ever experienced in my life. But it did dramatically reduce my depression symptoms.
Ayahuasca Psychedelic Tested for Depression - Scientific American
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I have a friend who couldn't tolerate anti-depressants and is now on Ketamine. She sees a specialist for infusions in sets of three and has to drive from one side of her state to the other for them. She also takes it in a compounded formula from a local pharmacy between treatments. It is working wonders, however she is not an addict. In addition, during the effects of the daily medication dose she has limited function. Cure all or magic pill? Not even close to it until they can isolate the compound that helps the depression without all the horrible side effects.
Her case is the extreme though. She was being hospitalized for her depression several times a year when she became actively suicidal. For her, giving up several hours of her day to the medication is a legitimate trade-off. She's also under intense medical supervision.
Her case is the extreme though. She was being hospitalized for her depression several times a year when she became actively suicidal. For her, giving up several hours of her day to the medication is a legitimate trade-off. She's also under intense medical supervision.
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The FDA has now approved a form of ketamine for the treatment of depression. It will cost $590-$885 before discounts.
https://www.circa.com/story/2019/03/...GQElUqACWF6yCk
https://www.circa.com/story/2019/03/...GQElUqACWF6yCk
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